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Health.cat news The New England Journal of Medicine: Search Results
The New England Journal of Medicine (NEJM) RSS feed -- Search Results. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Osimertinib in Untreated EGFR-Mutated Advanced Non?Small-Cell Lung Cancer
31/12/69 - The current standard of care for patients with locally advanced or metastatic non?small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)?sensitizing mutations is treatment with a first-generation or second-generation EGFR-TKI such as…

Diuretic Treatment in Heart Failure
31/12/69 - Most accepted pharmacologic treatments for heart failure are supported by evidence from large clinical trials. In contrast, evidence from large, well-controlled clinical trials to guide the use of diuretics, among the most frequently used drugs in heart failure, is generally lacking. Fluid…

Durvalumab after Chemoradiotherapy in Stage III Non?Small-Cell Lung Cancer
31/12/69 - Approximately one third of patients with non?small-cell lung cancer (NSCLC) have stage III, locally advanced disease at diagnosis. The standard of care for patients with a good performance status and unresectable stage III NSCLC is platinum-based doublet chemotherapy concurrent with radiotherapy…

Case 35-2017: A 57-Year-Old Woman with Hypoesthesia and Weakness in the Legs and Arms
31/12/69 - Presentation of Case. Dr. Daniel B. Rubin (Neurology): A 57-year-old-woman was admitted to this hospital because of progressive hypoesthesia, paresthesia, and weakness in the arms and legs. The patient had been in her usual health until 18 months before this admission, when paresthesia developed in…

Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease
31/12/69 - Autosomal dominant polycystic kidney disease (ADPKD) is the fourth leading cause of end-stage kidney disease in adults. When the genes encoding polycystin 1 (PKD1) and polycystin 2 (PKD2) are disrupted, tubular epithelial cells in vasopressin-sensitive distal nephrons and collecting ducts show…

Sudden Cardiac Arrest during Participation in Competitive Sports
31/12/69 - The occurrence of sudden cardiac arrest in young persons during participation in competitive sports is a rare but tragic event. In numerous jurisdictions, preparticipation screening systems have been implemented on the assumption that most cases of sudden cardiac arrest that occur during sports…

An Unusual Cause of Leg Pain
31/12/69 - A 67-year-old woman presented to her primary care physician with pain in her legs. Approximately 7 weeks earlier, she had noticed a cramping sensation in the back of both thighs and both calves that occurred after walking a couple of blocks and was relieved with rest. . . .

Lomustine and Bevacizumab in Progressive Glioblastoma
31/12/69 - No standard of care has been established for patients with progressive glioblastoma. Previous studies suggested that bevacizumab, a monoclonal antibody that targets vascular endothelial growth factor, is safe and produces responses that result in a decreased use of glucocorticoids and increased…

Tolvaptan and Autosomal Dominant Polycystic Kidney Disease
31/12/69 - Approximately half the patients with autosomal dominant polycystic kidney disease (ADPKD), a condition due to deficiency in polycystin 1 or 2, have end-stage kidney disease by 60 years of age. Once progression begins, the mean decline in the estimated glomerular filtration rate (GFR) is…

Immunotherapy for Unresectable Stage III Non?Small-Cell Lung Cancer
31/12/69 - In this issue of the Journal, Antonia and colleagues report the results of the phase 3 PACIFIC study, which evaluated the role of immune checkpoint blockade in locally advanced, unresectable, stage III non?small-cell lung cancer (NSCLC). Eligible patients had disease that had not yet progressed…

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