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Health.cat news The New England Journal of Medicine: Search Results
The New England Journal of Medicine (NEJM) RSS feed -- Search Results. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Five-Year Outcomes with PCI Guided by Fractional Flow Reserve
31/12/69 - Among patients with acute coronary syndromes, early percutaneous coronary intervention (PCI) increases the survival rate and decreases the rate of recurrent myocardial infarction. In contrast, in patients with stable coronary artery disease, there is persistent controversy about the role and timing…

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma
31/12/69 - Approximately 20% of patients with asthma have uncontrolled, moderate-to-severe disease with recurrent exacerbations and persistent symptoms despite maximized standard-of-care controller therapy. This population is at an increased risk for illness (especially exacerbations) and accounts for…

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma
31/12/69 - An estimated 45% of patients with severe asthma use systemic glucocorticoids to control the disease and prevent exacerbations. However, systemic glucocorticoids act nonselectively and are associated with considerable multiorgan toxic effects and broad immunosuppression. The use of the currently…

New Biologics for Asthma
31/12/69 - Two articles now published in the Journal indicate that dupilumab, a monoclonal antibody directed against the alpha subunit of the interleukin-4 receptor that inhibits interleukin-4 and interleukin-13 signaling, has a salutary treatment effect in severe asthma. In the first trial, patients with…

Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection
31/12/69 - The overuse of antibiotic agents is a public health problem associated with increased health care costs and antibiotic resistance. Overuse of antibiotics is common in infections of the lower respiratory tract, where bacterial and viral infections manifest similarly. Procalcitonin is a peptide with…

Case 15-2018: An 83-Year-Old Woman with Nausea, Vomiting, and Confusion
31/12/69 - Presentation of Case. Dr. Andrew S. Hoekzema (Medicine): An 83-year-old woman was admitted to this hospital in the winter because of nausea, vomiting, diarrhea, and confusion. One week before admission, rhinorrhea, sore throat, and nonproductive cough developed. The patient felt feverish but did…

Inhaled Combined Budesonide?Formoterol as Needed in Mild Asthma
31/12/69 - Mild asthma, which can be well controlled either with reliever medication (short-acting ?2-agonists [SABAs]) used alone as needed or with low-dose inhaled glucocorticoid or leukotriene-receptor antagonist used as maintenance controller medication, occurs in approximately 50 to 75% of patients with…

Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes
31/12/69 - Familial Mediterranean fever, mevalonate kinase deficiency (also known as the hyperimmunoglobulinemia D syndrome), and the tumor necrosis factor receptor?associated periodic syndrome (TRAPS) are monogenic autoinflammatory diseases that are characterized by recurrent fever episodes, with variable…

Improving the Supply and Quality of Deceased-Donor Organs for Transplantation
31/12/69 - Organ transplantation is the treatment of choice for many patients with end-stage diseases, but the supply of organs that are considered acceptable according to current criteria is limited. Approaches to reducing the increasing gap between demand for and availability of donated organs have focused…

Leadership Development in Medicine
31/12/69 - Health care in the United States suffers from a persistent and worsening disconnect between the capacity of the physician-leadership workforce and the needs of our expanding and increasingly complex health systems. Closing this gap will require leadership skills that are not acquired during…

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